His resignation comes as Amazon rapidly expands in India, planning to invest $26 billion by 2030, despite facing a stringent regulatory environment that mandates it operate solely as a marketplace.
Amazon stated that Tiwary decided to pursue an opportunity outside the company and will remain until October to ensure a smooth transition.
Amit Agarwal, senior vice president for emerging markets, will stay closely involved with the India team.
"India is an important priority," Amazon noted in its statement.
The e-commerce giant is currently under antitrust investigation for allegedly favouring select sellers on its Indian website, an accusation it denies.
In 2021, Reuters reported that Amazon engaged in a systematic campaign of creating knockoff goods and manipulating search results to promote its own product lines in India, practices the company has denied.