The accident took place at around 8 am near the Hindu Cemetery in the Topsia area.
According to preliminary information, a speeding SUV suddenly lost control, crossed the central divider and crashed into an oncoming vehicle on the opposite side of the flyover.
Both occupants involved in the collision suffered serious injuries, sources said.
After receiving information about the accident, police from Topsia police station reached the spot and arranged for the injured to be taken to hospital.
One injured person was taken to SSKM Hospital, while the other was admitted to another hospital.
Police are investigating the circumstances that led to the collision, including whether the driver of the SUV was under the influence of alcohol at the time of the accident.
Police have taken both vehicles to Topsia police station as part of the investigation.