Kyiv/Moscow: Russia has launched an Inter-Continental Ballistic Missile (ICBM) at Ukraine, marking a major escalation a day after President Vladimir Putin altered Moscow's nuclear doctrine, media reports said.

The ICBM, armed with a conventional (non-nuclear) warhead, serves as a stern warning to Ukraine and its Western backers to respect Moscow’s red lines.

Traditionally designed to carry nuclear warheads, ICBMs can also be equipped with conventional ones, leveraging the advanced technology originally developed for nuclear deterrence.

The launch follows the decision by U.S. President Joe Biden and UK Prime Minister Keir Starmer to allow Ukraine to deploy Western long-range missiles against Russian territory.

Hours after Kyiv received approval, it targeted Russian areas using a U.S.-made ATACMS missile and a UK-made "Storm Shadow" missile.

The ICBM strike, reportedly the first of its kind in the conflict, comes as the war reaches its 1,000th day.

The Ukrainian Air Force stated that the missile was launched from Russia’s Astrakhan region, targeting infrastructure in Dnipro, a central Ukrainian city.

“This is the first time since the war began that an intercontinental ballistic missile has been used,” a Ukrainian Air Force source told AFP.

When asked about the ICBM, Kremlin spokesperson Dmitry Peskov declined to comment, stating he had "nothing to say on this topic."